其 他 安 全 警 示
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| The United Kingdom: Non-steroidal anti-inflammatory drugs (NSAIDs) and risk of heart problems (English Only) |
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MHRA advice on the use of non-steroidal anti-inflammatory drugs (NSAIDs) remains the same despite a review by Hull York Medical School linking these drugs with an increased risk of heart attack or stroke. The findings of this study are not new; an increase in risk of heart attack and stroke with some NSAIDs has been well recognised for some years, particularly with long-term use of high doses and in patients who are already at high risk. The safety profile of all NSAIDs, and in particular their possible association with adverse cardiovascular effects, such as heart attack or stroke, has been carefully evaluated by the MHRA, on many occasions, as new data has become available. Clear information about the risk of heart problems, along with information about those patient groups in which NSAIDs either should not be used (such as those with severe heart failure) or used with caution, are contained in the information for healthcare professionals and the leaflet for patients that accompanies the medicine. To minimise the risk of side effects NSAIDs should be used for the shortest time and lowest dose necessary to control symptoms. The MHRA keeps the safety of NSAIDs under close review and will carefully evaluate any important new data to determine whether it has any implications for patient safety and will take any action necessary to minimise the risk to patients.
Please refer to the following website in MHRA for details:
http://www.mhra.gov.uk/Safetyinformation/Safetywarningsalertsandrecalls/Safetywarningsandmessagesformedicines/CON129228
In Hong Kong, NSAIDs-containing products are registered pharmaceutical products with ingredients such as diclofenac, ibuprofen, indomethacin, mefenamic acid and piroxicam. In view of MHRA's recommendation, a letter to inform healthcare professionals will be issued and the matter will be discussed in the meeting of the Registration Committee of the Pharmacy and Poisons Board.
Ends/ Friday, September 30, 2011
Issued at HKT 12:30
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