Strengthening the Sales Control of Pharmaceutical Products (i) for Human Parenteral Administration and (ii) containing Designated Vitamin

The Pharmacy and Poisons (Registration of Pharmaceutical Products & Substances: Certification of Clinical Trial/Medicinal Test) Committee (the Committee) under the Pharmacy and Poisons Board has recently reviewed the sales control of two categories of pharmaceutical products, including those (i) for human parenteral administration, and (ii) containing designated vitamins, which are currently sold as non-prescription drugs in Hong Kong

The Committee considered that there are potential risks when these products are sold without prescriptions to the patients. With reference to the sales restriction of these products in some overseas countries (e.g. the United States, the United Kingdom, Australia, Canada, and Singapore) and based on the available scientific information, the Committee decided that the sales control of these products should be strengthened (i.e. to be sold under prescription) for protection of public health.

In this regard, the gazette of amendment to the Pharmacy and Poisons Regulations (the Regulations) (Cap. 138A) for the above is published on 20 January 2017.

According to the gazette, at the expiry of six months from the date of gazette, the pharmaceutical products for human parenteral administration containing the substances listed at Appendix I or their salts, as active ingredient, except when they are in mixture with insulin; and the pharmaceutical products containing the designated vitamins at Appendix II, will be added to Schedule 1, Schedule 3, and Part 1 of Schedule 10 (i.e. prescription-only medicines) of the Regulations. In addition, at the expiry of 12 months from the date of gazette, the pharmaceutical products for human parenteral administration containing sodium chloride 0.9% or water as active ingredient will also be added to Schedule 1, Schedule 3, and Part 1 of Schedule 10 of the Regulations.

The registration certificate holders of the above affected products should review their products and comply with the labelling requirements by including the bilingual statement of "Prescription Drug 處方藥物" on the sales pack of the products. Any illegal sale of Part 1, First and Third Schedule poisons without a prescription, and the sale of medicine not complying with the above labelling requirements are offences under the Pharmacy and Poisons Ordinance and Regulations, of which the maximum penalty for each offence is a fine of $100,000 and two years' imprisonment.

Please visit the following Drug Office websites on:

Letter to Trade on Strengthening the Sales Control of Pharmaceutical Products (i) for Human Parenteral Administration and (ii) containing Designated Vitamins

Appendix I: Pharmaceutical products containing the following substances or their salts as active ingredient for human parenteral administration

1. Acetic acid 22. Difenidol 58. Omeprazole
2. Acetycholine 23. Diprophylline 59. Oxidronate
3. Acetylcysteine 24. Disofenin 60. Papaverine
4. Adenosine 25. Ephedrine 61. Paracetamol
5. Adrenaline 26. Exametazime 62. Patent blue V
6. Ambroxol 27. Fish Oil 63. Pentetic acid
7. Amino acids 28. Fluorescein 64. Pentoxifylline
8. Aminophylline 29. Gallium 65. Phenol
9. Anti-D (rho) 30. Gelatin 66. Phenylephrine
    immunoglobulins 31. Glucosamine 67. Piracetam
10. Anti-histamine 32. Glucose 68. Procaine
      substances 33. Glycerol 69. Protamine
11. Atropine 34. Glyceryl trinitrate 70. Ranitidine
12. Betiatide 35. Guaifenesin 71. Rhenium
13. Bicisate 36. Heparin 72. Sodium
14. Butetamate 37. Hyaluronic acid       pyrophosphate
15. Caffeine 38. Hyaluronidase 73. Sodium tetradecyl
16. Carnitine 39. Hydroxyethyl starch       sulfate
17. Cations, the following, except in preparations containing any substance to which the Antibiotics Ordinance (Cap. 137) applies:
Calcium,
Chromium,
Copper,
Iron,
Magnesium,
Manganese,
Potassium,
Selenium,
Sodium (except sodium chloride 0.9%),
Zinc
40. Hyoscine 74. Sodium thiosulfate
41. Icodextrin 75. Sorbitol
42. Indocyanine green 76. Soya oil
43. Iodine norcholesterol 77. Stonefish antivenom
44. Isosorbide 78. Succimer
45. Lactic acid 79. Terbutaline
46. Lecithin 80. Tetrakis copper
47. Lignocaine       tetrafluoroborate
48. Mannitol 81. Tetrofosmin
49. Mebrofenin 82. Thallium
50. Medronic acid 83. Tin
51. Mesna 84. Triglycerides
52. Methoxyphenamine 85. Tubercullin
53. Methylene blue 86. Vitamins
18. Choline 54. Methylephedrine 87. Xantinol nicotinate
19. Cimetidine 55. Metronidazole  
20. Dextromethorphan 56. Noradrenaline  
21. Dicycloverine 57. Olive oil  


Appendix II: Designated Vitamins

1. Alfacalcidol; its salts
2. Calcitriol, its salts
3. Vitamin D and its salts when contained in pharmaceutical products the
    recommended daily dose of which contains more than 1,000 international
    units of vitamin D
4. Vitamin K and its salts when contained in pharmaceutical products, except
    products with recommended daily dose of 120mcg or less of vitamin K1 or
    K2 or its salts



Ends / Friday, January 20, 2017